Tyrosols and derivatives
Selleck Chemical LLC VX-702
VX-702 is a highly selective inhibitor of p38 MAPK 14-fold higher potency against the p38 versus p38
Apexbio Technology LLC VX-702 479543-46-9; 745833-23-2 10mM (in 1mL DMSO)
VX-702 is a small-molecule inhibitor targeting p38 mitogen-activated protein kinase (MAPK) also known as MAPK14 It is designed to inhibit p38 MAPK thereby regulating cellular responses to cytokine signaling and various stressors VX-702 exerts its biological activity primarily through ATP-competitive inhibition In experimental models VX-702 demonstrates potent inhibition with reported IC50 values ranging from 4 to 20 nM Based on these pharmacological properties VX-702 holds research potential in the study of p38 MAPK-dependent pathways platelet storage lesions and renal excretion mechanisms
Selleck Chemical LLC ABT 702 dihydrochloride
ABT-702 is a novel potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1 7 nM It has oral activity in animal models of pain and inflammation